Novartis’ candidate chimeric antigen receptor T (CAR T) cell therapy for cancer is scheduled to be reviewed on 12 July by the US Food and Drug Administration’s Oncologic Drugs Advisory Committee, according to Oxford BioMedica Plc, which is supplying lentiviral vector for the product.
Merck KGaA has taken steps to bolster its immuno-oncology portfolio with the signing of an option and collaboration agreement with F-star Biotechnology Ltd to develop five bispecific antibody compounds. A bispecific antibody is an engineered molecule that binds to two different antigens.
Bicycle Therapeutics Ltd has raised £40 million in a Series B financing round to bring its first peptide-based therapeutic into the clinic. The financing was led by Vertex Ventures, along with Cambridge Innovation Capital and the Longwood Fund.
A cartilage repair product developed by co.don AG of Germany received a positive opinion from the European Medicines Agency on 19 May, making it the ninth advanced therapy medicinal product (ATMP) to be assessed for marketing in Europe.
Heptares Therapeutics has described the structure of the glucagon-like peptide-1 (GLP-1) receptor binding to a peptide agonist, giving the first visual evidence of how a class of drugs that treat Type 2 diabetes actually work. The findings were reported online in Nature on 31 May 2017.
A novel vaccine platform developed by Hookipa Biotech AG has triggered an immune response in genetically engineered mice with cancer that was stronger than many conventional viral vectors. The findings were published on 26 May 2017 in Nature Communications.
Merck & Co Inc’s checkpoint inhibitor Keytruda (pembrolizumab) has been approved in the US for multiple solid tumours that have a common genetic feature known as microsatellite instability-high or mismatch repair deficit.
The Novartis tyrosine kinase inhibitor Zykadia (ceritinib) has been approved in the US for the first-line treatment of ALK-positive non-small cell lung cancer following Phase 3 data that showed a significant improvement in progression free survival in patients with the disease.
Epidiolex, a cannabinoid drug for a type of childhood epilepsy known as Dravet syndrome has reduced the frequency of seizures in a Phase 3 trial of children and adolescents with the disease, all of whom were not getting relief from current treatments.
Belgium-based Argenx NV has made its debut on the Nasdaq over-the-counter market in the US, capping what has been nearly a decade of successful antibody discovery and development. On 17 May, it announced the pricing of an initial public offering (IPO) of its shares that was set to yield $100 million.